Expanded PCR panel for uropathogen identification and treatment recommendations in urinary tract infections
Therapeutic Advances in Urology
Jun 10, 2025
Lindsey Leech, Christopher Bigley, Marshall Chew, Ashley Crawford, JeanAnn Vawter, and Manish P. Patel
Urinary tract infections (UTI) are common and costly, but standard urine culture (SUC) diagnostic tests have significant limitations. Emerging molecular techniques like multiplex polymerase chain reaction (PCR) offer rapid simultaneous detection of uropathogens and antimicrobial resistance (AMR) genes allowing timely targeted therapy.
Primed for Global Coronavirus Pandemic: Emerging Research and Clinical Outcome
European Journal of Medicinal Chemistry
Sep 19, 2020
Shakir Ahamada, Scotty Branch, Shea Harrelson, Mohd Kamil Hussain, Mohammad Saquib, and Saeed Khan
The global effort to combat and contain the coronavirus disease 2019 (COVID-19) pandemic is now proceeding on a war footing. The world was slow to react to the developing crisis, but once the contours of the impending calamity became evident, the different state and non-state actors have raced to put their act together. The COVID-19 outbreak has blatantly exposed the shortcomings of our healthcare system and the limitations of medical science, despite considerable advances in recent years. To effectively tackle the current epidemic, almost unprecedented in the modern era, there is an urgent need for a concerted, sustained, and coordinated effort towards the development of new diagnostics, therapeutic and vaccines, and the ramping up of the healthcare infrastructure, especially in the poorer, underprivileged nations.
Respiratory Microbial Co-infection With SARS-CoV-2
Frontiers in Microbiology
Aug 25, 2020
Bill W. Massey, Karuna Jayathilake, and Herbert Y. Meltzer
Co-infection with additional pathogens is a well-known feature of pandemics. We determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens, which on their own produce at least some SARS-CoV-2 symptoms including mortality, were present in both SARS-CoV-2 + and SARS-CoV-2- subjects.